Statistics Seminar: Anne Shiu -- The Cyclohedron Test for Finding Periodic Genes in Time Course Expression Studies

Anne Shiu
Department of Mathematics
University of California, Berkeley

Location: Carslaw 828 (*** GRID room ***)

Time:  5pm Monday, May 24, 2010 (****)

Title: The Cyclohedron Test for Finding Periodic Genes in Time Course Expression Studies 

Abstract:
The problem of finding periodically expressed genes is at the center
of numerous efforts to identify the molecular components of
biological clocks. We present an approach to this problem appropriate
for analyzing microarray data, based on the cyclohedron test, which
is a rank test inspired by recent advances in algebraic
combinatorics.  This talk will highlight the statistics and
combinatorics that underlie the cyclohedron test and its
implementation, in light of multiple hypothesis testing concerns.  No
prior knowledge of microarray data analysis, combinatorics, or
multiple testing will be assumed.