Adarsh Kumbhari

Applied Mathematician, University of Sydney

I'm a math biologist interested in developing realistic mathematical and computational models of biological systems, that can provide novel, experimentally verifiable insights. I model cancer treatments and cell systems using whatever tool is appropriate for the problem at hand (which often means a combination of ODEs, ABMs, and PDEs). Later this year I'll be moving to the Smillie Lab as Postdoctoral Associate.

Current Research

Cancer vaccines

The immune system can be modulated to kill cancer cells. I look at how vaccines can be leveraged to achieve this.

PD-1/PD-L1 regulation

PD-L1 is a molecule upregulated by tumours that inhibits immune activity. I study how this cross-talk shapes the overall immune response.

Mitochondrial dynamics

Mitochondria are the powerhouse of the cell and when things go awry the results are bad. I examine how the organisation of mitochondria in the heart affects cardiac performance.

Gut microbiome

The gut microbiome, when disturbed, can lead to disease. However, our understanding of how microbiome-tissue interactions give rise to disease remains incomplete. I develop mathematical models and computational tools to identify interactions between the microbiome, human tissues, and disease.


For more details, my CV is available here.